Effects of Fermented Papaya Preparation (FPP) on Safety Outcomes in Older Adults - A Short Report of a Placebo-Controlled Clinical Trial.
Mankowski, Leeuwenburgh, Manini, et al. The Journal of frailty & aging, 2018.
Study design: Placebo-controlled randomized crossover clinical trial in 30 elderly people aged 70 to 100; fermented papaya at 9 g per day for 8 weeks per phase with a 4-week washout.
- There were no adverse changes in blood chemistry, and the incidence of side effects did not differ from placebo.
- There were no serious side effects in either condition.
- A total of 29 participants (mean age 78.2 years) completed the study with 94 percent dose compliance.
- There were no significant effects on anthropometric, metabolic, or inflammatory markers.
What it means for your product: Useful safety data for the dossier of products targeting older consumers. This study showed no metabolic benefit, so it cannot be used for function claims.









