Carica papaya extract in dengue: a systematic review and meta-analysis.
Rajapakse, de Silva, Weeratunga, et al. BMC complementary and alternative medicine, 2019.
Study design: Systematic review and meta-analysis of 9 controlled studies (India 6, Pakistan 1, Indonesia 1, Malaysia 1) on Carica papaya extract in dengue patients.
- Seven studies reported a rise in platelet count in the groups receiving the extract, and one study found no significant difference.
- Hospital stay was shorter: mean difference -1.98 days (3 studies, 580 participants, low-quality evidence).
- No serious adverse effects were reported.
- The authors concluded that the evidence is not yet sufficient to assess the role of papaya extract in dengue.
What it means for your product: This research explains why papaya leaf is in market demand. However, this is a patient context, not a basis for product claims; dengue remains a matter for medical professionals.









