Safety Evaluation and Plasma Carotenoid Accumulation in Healthy Adult Subjects after 12 Weeks of Paprika Oleoresin Supplementation.
Umigai, Murakami, Shimizu, et al. Journal of oleo science, 2018.
Study design: Double-blind, placebo-controlled clinical study in 33 healthy adults randomized to paprika oleoresin capsules of 0, 20, or 100 mg per day for 12 weeks.
- Plasma beta-cryptoxanthin and zeaxanthin increased with dose over 12 weeks.
- Beta-cryptoxanthin accumulated the most of all paprika carotenoids.
- Capsanthin, in contrast, was not detected in plasma before or during the 12 weeks.
- There were no side effects related to paprika oleoresin at 20 and 100 mg/day on blood and urine tests.
What it means for your product: Useful early safety data for a dossier. However, capsanthin was not measurable in blood, so do not link systemic benefits directly to capsanthin.









