Association of Major Food Sources of Fructose-Containing Sugars With Incident Metabolic Syndrome: A Systematic Review and Meta-analysis.
Semnani-Azad, Khan, Blanco Mejia, et al. JAMA network open, 2020.
Study design: Systematic review and meta-analysis of thirteen prospective cohort studies on fructose-containing sugar food sources and the incidence of metabolic syndrome.
- Fruit showed a protective association: risk ratio 0.82 for 80 g per day.
- Mixed fruit juice and 100% juice were protective at moderate amounts (RR 0.58 and 0.77 for 125 mL per day), with a U-shaped pattern.
- Sugar-sweetened beverages, in contrast, were associated with higher risk (RR 1.14 for 355 mL per day).
- Certainty of evidence was moderate for fruit and fruit juice.
What it means for your product: Moderate amounts are key. Fruit premixes are best positioned without added sugar and with a reasonable serving size.









